Annotation

V.D.Lakhno, E.V.Sobolev, N.S.Fialko, V.V.Baryshnikov, L.А.Kirzhemanov. Database on charge transfer in DNA //The 10-th International Conference on "Mathematics. Computer. Education", 20-25 Jan. 2003, Pushchino : Abstracts. (in print).

      The Institute of Mathematical Problems of Biology, RAS has been engaged in the studies on modeling charge transfer in DNA for several years. The aim of the studies has been to identify functional parameters determining the electron transfer rate in nucleotide sequences, such as temporal dependencies of the probabilities of the electron density distribution, displacements of Watson-Crick pairs attendant the transfer process, etc. Numerical experiments provide a great body of information on electron transfer rates for different DNA fragments. These data require systematization which makes still more acute the problem of creating a relevant database. Such a database could be used to diagnose genetic diseases, to calculate elements of circuits in DNA-based nanoelectronic devices, etc.